Published In
Turkish Journal of Nephrology
Volume 23 · Issue 2
Pages: 118-124
History
Published Online: February 8, 2019
Copyright © 2014 Turkish Journal of Nephrology
Ayşe ÇARLIOĞLU
Turgut Özal Üniversitesi Tıp Fakültesi,
Endokrinoloji Bilim Dalı,
Ankara, Türkiye
Derya AKDENİZ
Turgut Özal Üniversitesi Tıp Fakültesi,
İç Hastalıkları Anabilim Dalı,
Ankara, Türkiye
Rabia ALKAN
Turgut Özal Üniversitesi Tıp Fakültesi,
İç Hastalıkları Anabilim Dalı,
Ankara, Türkiye
Ebru UZ
Turgut Özal Üniversitesi Tıp Fakültesi,
Nefroloji Bilim Dalı, Ankara, Türkiye
Hacer HALTAS
Turgut Özal Üniversitesi Tıp Fakültesi,
Patoloji Anabilim Dalı, Ankara, Türkiye
Faruk TURGUT
Turgut Özal Üniversitesi Tıp Fakültesi,
Nefroloji Bilim Dalı, Ankara, Türkiye
Sema UYSAL
Turgut Özal Üniversitesi Tıp Fakültesi,
Biyokimya Anabilim Dalı,
Ankara, Türkiye
ÇARLIOĞLU, A., AKDENİZ, D., ALKAN, R., UZ, E., HALTAS, H., TURGUT, F., & UYSAL, S. (2019). The Effect of Zofenopril on Pancreas, Kidney and Liver of Diabetic Rats. Turkish Journal of Nephrology, 23(2), 118–124. Retrieved from https://www.turkjnephrol.org/index.php/pub/article/view/941
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Abstract
OBJECTIVE: Oxidative stress is responsible for some important complications of diabetes mellitus. Zofenopril, which has an antioxidant effect, may decrease the oxidative stress of the diabetic microenvironment. The aim of our study was to evaluate the effect of zofenopril in the liver, pancreas and kidney of alloxan-induced diabetic rats.
MATERIAL and METHODS: Rats were divided into five groups: control group (n=6), rats treated with zonenopril (50 mg/kg/day, orally four weeks; n=6), rats exposed to alloxane (120 mg/kg single dose intraperitoneal injection, n=6), rats administered alloxan+zofenopril (n=6) and rats administered insulin plus alloxan.
RESULTS: After one month, we observed histological improvement in the kidneys but not in the pancreas and liver.
CONCLUSION: In conclusion, zofenopril may be effective on the renal complications of diabetes mellitus.
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Article Info
Published In
Journal
Turkish Journal of Nephrology
Volume / Issue
Volume 23 · Issue 2
Pages
118-124
History
Published Online
February 8, 2019
Copyright
Copyright (c) 2014 Turkish Journal of Nephrology
Affiliations
Ayşe ÇARLIOĞLU
Turgut Özal Üniversitesi Tıp Fakültesi,
Endokrinoloji Bilim Dalı,
Ankara, Türkiye
Derya AKDENİZ
Turgut Özal Üniversitesi Tıp Fakültesi,
İç Hastalıkları Anabilim Dalı,
Ankara, Türkiye
Rabia ALKAN
Turgut Özal Üniversitesi Tıp Fakültesi,
İç Hastalıkları Anabilim Dalı,
Ankara, Türkiye
Ebru UZ
Turgut Özal Üniversitesi Tıp Fakültesi,
Nefroloji Bilim Dalı, Ankara, Türkiye
Hacer HALTAS
Turgut Özal Üniversitesi Tıp Fakültesi,
Patoloji Anabilim Dalı, Ankara, Türkiye
Faruk TURGUT
Turgut Özal Üniversitesi Tıp Fakültesi,
Nefroloji Bilim Dalı, Ankara, Türkiye
Sema UYSAL
Turgut Özal Üniversitesi Tıp Fakültesi,
Biyokimya Anabilim Dalı,
Ankara, Türkiye
Cite this Article
ÇARLIOĞLU, A., AKDENİZ, D., ALKAN, R., UZ, E., HALTAS, H., TURGUT, F., & UYSAL, S. (2019). The Effect of Zofenopril on Pancreas, Kidney and Liver of Diabetic Rats. Turkish Journal of Nephrology, 23(2), 118–124. Retrieved from https://www.turkjnephrol.org/index.php/pub/article/view/941
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