Acute Tubulointerstitial Nephritis: Presentation of Four Cases

Nonsteroidal anti-inflammatory drugs and paracetamol (acetaminophen) which are analgesic-antipyretic drugs are thought to be safe and are most commonly used in children to control pain and fever.

We retrospectively analysed the clinical and laboratory characteristics of four patients who were admitted between 2009-2011 and diagnosed as acute renal failure with a history of analgesic-antipyretic drugs usage. Two of them used flurbiprofen and the other two paracetamol. None of them had any chronic disease. The time between medication and admission to hospital was 3-20 days. Renal biopsy was performed in all patients showing tubulointerstitial inflammation. One patient was given corticosteroid therapy and the other three were treated with hydration only. Renal function tests became normal in 4-9 days. Two of three patients who had proteinuria at admission had normal urinalysis at discharge.