Malignancy After Renal Transplantation: A Single-Center Experience

AIM: The aim of present the study was to evaluate development of malignancy in the renal transplant recipients who were followed up from 05.05.1994 to 31.01.2008 in Erciyes University Faculty of Medicine.

MATERIAL and METHOD: The patients with post-transplant malignancy among the 123 renal transplant recipients were included in the study.

RESULTS: The donor source was living donor in 77 (62.6%) and cadaver donor in the rest of them. The mean age was 32.3±7.6 (range 17-65) years. Lymphoma and skin cancer were detected in four and three renal transplant recipients, respectively. Also two female patients developed ovary and cervix carcinoma. All patients with lymphoma received chemotherapy. These patients with skin, ovary, and cervix cancer were operated. In all patients with posttransplant malignancy, the dose of immunosuppressive drugs were reduced or modified after treatment of malignancy. Two patients with lymphoma died due to infection. The other patients with post-transplant malignancy have been followed-up with functional graft and complete remission.

CONCLUSION: The malignancies developed more frequently than normal population after renal transplantation. The post-transplant malignancies were lymphomas and skin and gynecological cancers