THE EFFECTS OF TRANDOLAPRİL AND LOSARTAN ON GLOMERULO-TUBULER FUNCTION IN PRIMARY HYPERTENSION

İn primary hypertension (HT), organs are damaged by vascular disturbance. The kidney is a major end organ in HT. In antihypertensive theraphy; beside the aim of lowering the blood pressure, use of preparations with organ protective properties is also important. In our study, markers of glomerulo-tubuler function were investigated in 63 HT patients with mean blood pressure (SBP) 158.9± 11.4 mmHg, diyastolic blood pressure (DBP) 99.7 ±6.9 mmHg and compared to 41 healthy individuals. In HT group, the effects of six months trandolapril and losartan theraphy on renal functions were evaluated. In patients group, uric acid (ÜA), proteinuria, urinary albumin excretion (UAE), urinary Nacetyl β-u glucozaminidase (NAG) and Beta-2- microglobulin $2m) excretion were significantly higher than the control group's. There were a positive linear correlation between UAE and body mass index (BMI), proteinuria, GFR; urinary NAG excretion and SBP, DBP, fi2m excretion and SBP. With a two week salt limited diet, levels of SBP, DBP and Nα' were significantly decreased Trandolapril theraphy lead to a significant decrease in proteinuria, UAE, urinary NAG excreation. UA, proteinuria, UAE, urinary NAG and fi2m excretions were seen to be significantly decreased with losartan treatment.

Our results show, in patient groups significant glomerulo-tubuler dysfunction were found at early stage. Antihypertensive and renoprotective effects of trandolapril and losartan were found similar.