IS MICROALBUMINURIA A MARKER OF SYSTEMIC AND RENAL ENDOTHELIAL DEMAGE IN ESSENTIAL HYPERTENSION?

Study was performed on 168 patients with essential hypertension (HT). Their SBP, DBP were 161,4±16 and 100,8±8 mmHg. Mean age was 47,6±9 years and HT duration was 46,8±4 months. 88 healthy subjects with mean age 46,4±9 years were included as a control. Endogenous creatinine clearance (GFR), proteinuria, urinary albumin excretion in minute (UAE) were measured. Plasma fibrinogen, vonWillebrand factor (vWF), serum lipoprotein, uric acid, electrolytes were measured. Proteinuria (P:0,019), UAE (P:0,000), fibrinogen (P:0,003), vWF (P:0,012), triglyceride (P: 0,001) and uric acid (P:0,000) values were higher in HT group. Microalbuminuria (MA) was observed %3,4 in control and %32 in HT group. There was %65 hypertensive retinopathy in patients. Our observations suggest that HT effects the systemic and renal endothelium at early stage.