Evaluation of Renin, Aldosterone, Angiotensin, and Lipid Metabolism Genes and Genotype-Phenotype Relationship in Childhood Primary Hypertension Pathogenesis

Purpose: Childhood primary hypertension(HT) has been increasing in parallel with the increase in obesity prevalence in recent years. Hypertension is a polygenic disease in which epigenetic changes are also effective. In this study, factors and gene polymorphisms in HT etiology were evaluated.

Material and methods: Age, gender, body mass index(BMI), family history, blood glucose and lipid levels, blood pressure (BP) measurements and percentiles at the time of diagnosis, post-treatment BP controls, and target organ involvement were examined. Polymorphisms of ACE, renin, angiotensin, aldosterone, FABP2, ApoB100 were evaluated.

Results: A total of 100 patients, 50 patients(Group1) and 50 healthy controls(Group2) were included in the study. In terms of age distribution, patient and control groups were not similar(p=0.040). Distributions by gender were similar. While the mean height as one of the anthropometric values of both groups were statistically similar, the BMI of Group1 was significantly higher than the control group(p<0.001). In the biochemical tests, only the HDL mean of Group1 was significantly lower than that of Group2(p<0.001). When the distribution difference of ACE, renin, angiotensin, aldosterone, FABP2, ApoB100 polymorphism was examined, no statistically significant difference was observed.

Conclusion: In this study ACE, Renin, Angiotensin, Aldosterone, FABP2 and ApoB100 gene polymorphisms were not identified as risk factors in existing pathways.

Cite this article as: Özdemir Şimşek Ö, Berdeli A, Keskinoğlu A. Evaluation of renin, aldosterone, angiotensin, and lipid metabolism genes and genotype-phenotype relationship in childhood primary hypertension pathogenesis. Turk J Nephrol. 2022;31(4):368-374.