CHANGES IN ANTIBIOTIC SENSIVITY IN URINARY TRACT INFECTION CAUSED BY ESCHERICHIA COLI

Urinary tract infections are one of the major health problems in children and the most frequently encountered etiological agents is Escherichia coli.

Antibiotic sensivity and resistance of E. coli species yielded from the urinary cultures of patients diagnosed as urinary tract infection between 1992 and 1996 were reviewed retrospectively.

Resistance to ampicilline and trimethoprimsulphamethoxazole (TMP-SMX) were 54.1% and 40.8% respectively in 1992. The resistance increased significantly to 76.4% and 64.4% respectively in 1996 (p<0.001).

Resistance to other antibiotics were also reviewed. Rates of resistance to different antibiotics in 1992 and 1996 were as follows respectively: cefixim 1.9% and 4.1%, ceftriaxone 2.4% and 1.4 %, amicasin 1.6% and 7%,tobramycine 13.5% and 11.7% (p>0.05).

It was concluded that, resistance to antibiotic which are frequently used empirically for urinary tract infections had increased significantly between 1992 and 1996, thus the empirical treatment should be planned with taking into concideration of the resistance state.